Publications

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  • Domínguez-Robles J, Shen T, Cornelius VA, Corduas F, Mancuso E, Donnelly RF, Margariti A, Lamprou DA, Larrañeta E. Development of drug loaded cardiovascular prosthesis for thrombosis prevention using 3D printing. Mater Sci Eng C Mater Biol Appl. 2021 Oct;129:112375. doi: 10.1016/j.msec.2021.112375.
  • Cornelius VA, Fulton JR, Margariti A. Alternative Splicing: A Key Mediator of Diabetic Vasculopathy. Genes (Basel). 2021 Aug 27;12(9):1332. doi: 10.3390/genes12091332.
  • Byrne EM, Llorián-Salvador M, Tang M, Margariti A, Chen M, Xu H. IL-17A Damages the Blood-Retinal Barrier through Activating the Janus Kinase 1 Pathway. 2021 Jul 16;9(7):831. doi: 10.3390/biomedicines9070831.
  • Kelaini S, Chan C, Cornelius VA, Margariti A.RNA-Binding Proteins Hold Key Roles in Function, Dysfunction, and Disease. Biology (Basel). 2021 Apr 24;10(5):366. doi: 10.3390/biology10050366.
  • Angbohang A, Huang L, Li Y, Zhao Y, Gong Y, Fu Y, Mao C, Morales J, Luo P, Ehteramyan M, Gao Y, Margariti A, Gu W, Zhang M, Smith A, Shah AM, Li T, Kong W, Zeng L.X-box binding protein 1-mediated COL4A1s secretion regulates communication between vascular smooth muscle and stem/progenitor cells. J Biol Chem. 2021 Jan-Jun;296:100541. doi: 10.1016/j.jbc.2021.100541.
  • Martin NK, Domínguez-Robles J, Stewart SA, Cornelius VA, Anjani QK, Utomo E, García-Romero I, Donnelly RF, Margariti A, Lamprou DA, Larrañeta E.Fused deposition modelling for the development of drug loaded cardiovascular prosthesis. Int J Pharm. 2021 Feb 15;595:120243. doi: 10.1016/j.ijpharm.2021.120243. Epub 2021 Jan 21.
  • Cornelius VA, Yacoub A, Kelaini S, Margariti A.Diabetic endotheliopathy: RNA-binding proteins as new therapeutic targets. Int J Biochem Cell Biol. 2021 Feb;131:105907. doi: 10.1016/j.biocel.2020.105907.
  • Vilà González M, Eleftheriadou M, Kelaini S, Naderi-Meshkin H, Flanagan S, Stewart S, Virgili G, Grieve DJ, Stitt AW, Lois N, Margariti A. Endothelial Cells Derived From Patients With Diabetic Macular Edema Recapitulate Clinical Evaluations of Anti-VEGF Responsiveness Through the Neuronal Pentraxin 2 Pathway. Diabetes 2020 Oct;69(10):2170-2185. doi: 10.2337/db19-1068. 
  • Yang C, Eleftheriadou M, Kelaini S, Morrison T, González MV, Caines R, Edwards N, Yacoub A, Edgar K, Moez A, Ivetic A, Zampetaki A, Zeng L, Wilkinson FL, Lois N, Stitt AW, Grieve DJ, Margariti A. Targeting QKI-7 in vivo restores endothelial cell function in diabetes. Nature Communication 2020 Jul 30;11(1):3812. doi: 10.1038/s41467-020-17468-y.
  • O’Neill KM, Campbell DC, Edgar KS, et al. NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes post-ischaemic revascularization. Cardiovasc Res 2020;116:393-405.
  • Yang J, Moraga A, Xu J, et al. A histone deacetylase 7-derived peptide promotes vascular regeneration via facilitating 14-3-3γ phosphorylation. Stem Cells 2020;38:556-573.
  • Vilà-González M, Kelaini S, Magee C, et al. Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling. Stem Cells 2019;37:226-239.
  • Caines R, Cochrane A, Kelaini S, et al. The RNA-binding protein QKI controls alternative splicing in vascular cells, producing an effective model for therapy. J Cell Sci 2019;132.
  • Yang C, Kelaini S, Caines R, et al. RBPs play important roles in vascular endothelial dysfunction under diabetic conditions. Front Physiol 2018;9.
  • Yang C, Kelaini S, Caines R, et al. RBPs Play Important Roles in Vascular Endothelial Dysfunction Under Diabetic Front Physiol 2018;9:1310.
  • Tsifaki M, Kelaini S, Caines R, et al. Regenerating the Cardiovascular System Through Cell Reprogramming; Current Approaches and a Look Into the Future. Front Cardiovasc Med 2018;5:109.
  • Kelaini S, Vilà-González M, Caines R, et al. Follistatin-Like 3 Enhances the Function of Endothelial Cells Derived from Pluripotent Stem Cells by Facilitating β-Catenin Nuclear Translocation Through Inhibition of Glycogen Synthase Kinase-3β Activity. Stem Cells 2018;36:1033-1044.
  • Cochrane A, Kelaini S, Tsifaki M, et al. Quaking Is a Key Regulator of Endothelial Cell Differentiation, Neovascularization, and Angiogenesis. Stem Cells 2017;35:952-966.
  • Hong X, Margariti A, Le Bras A, et al. Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration. Sci Rep 2017;7:5590.
  • Hong X, Le Bras A, Margariti A, et al. Reprogramming towards endothelial cells for vascular regeneration. Genes Dis 2016;3:186-197.
  • Yang J, Margariti A, Zeng L. Analysis of Histone Deacetylase 7 (HDAC7) Alternative Splicing and Its Role in Embryonic Stem Cell Differentiation Toward Smooth Muscle Lineage. Methods Mol Biol 2016;1436:95-108.
  • Chen T, Margariti A, Kelaini S, et al. MicroRNA-199b Modulates Vascular Cell Fate During iPS Cell Differentiation by Targeting the Notch Ligand Jagged1 and Enhancing VEGF Signaling. Stem Cells 2015;33:1405-1418.
  • Zeng L, Li Y, Yang J, et al. XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling. Arterioscler Thromb Vasc Biol 2015;35:2134-2144.
  • Campagnolo P, Tsai T-N, Hong X, et al. c-Kit+ progenitors generate vascular cells for tissue-engineered grafts through modulation of the Wnt/Klf4 pathway. Biomaterials 2015;60:53-61.
  • Li Z, Margariti A, Wu Y, et al. MicroRNA-199a induces differentiation of induced pluripotent stem cells into endothelial cells by targeting sirtuin 1. Mol Med Rep 2015;12:3711-3717.
  • Kelaini S, Cochrane A, Margariti A. Direct reprogramming of adult cells: avoiding the pluripotent state. Stem Cells Cloning 2014;7:19-29.
  • Xu SS, Alam S, Margariti A. Epigenetics in vascular disease – therapeutic potential of new agents. Curr Vasc Pharmacol 2014;12:77-86.
  • Margariti A. Peripheral neuropathy may be a potential risk of cardiovascular disease in diabetes Heart 2014;100:1823-1824.
  • Martin D, Li Y, Yang J, et al. Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3. J Biol Chem 2014;289:30625-30634.
  • Di Bernardini E, Campagnolo P, Margariti A, et al. Endothelial lineage differentiation from induced pluripotent stem cells is regulated by microRNA-21 and transforming growth factor β2 (TGF-β2) pathways. J Biol Chem 2014;289:3383-3393.
  • Zeng L, Wang G, Ummarino D, et al. Histone deacetylase 3 unconventional splicing mediates endothelial-to-mesenchymal transition through transforming growth factor β2. J Biol Chem 2013;288:31853-31866.
  • Margariti A, Li H, Chen T, et al. XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. J Biol Chem 2013;288:859-872.
  • Zeng L, Xiao Q, Chen M, et al. Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation 2013;127:1712-1722.
  • Paschalaki KE, Starke RD, Hu Y, et al. Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased DNA damage and senescence. Stem Cells 2013;31:2813-2826.
  • Karamariti E, Margariti A, Winkler B, et al. Smooth muscle cells differentiated from reprogrammed embryonic lung fibroblasts through DKK3 signaling are potent for tissue engineering of vascular grafts. Circ Res 2013;112:1433-1443.
  • Margariti A, Winkler B, Karamariti E, et al. Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels. Proc Natl Acad Sci U S A 2012;109:13793-13798.
  • Zhou B, Margariti A, Zeng L, et al. Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis. Cardiovasc Res 2011;90:413-420.
  • Alam S, Li H, Margariti A, et al. Galectin-9 protein expression in endothelial cells is positively regulated by histone deacetylase 3. J Biol Chem 2011;286:44211-44217.
  • Zhou B, Margariti A, Zeng L, et al. Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation. Arterioscler Thromb Vasc Biol 2011;31:2676-2684.
  • Margariti A, Zampetaki A, Xiao Q, et al. Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin. Circ Res 2010;106:1202-1211.
  • Zhang L, Jin M, Margariti A, et al. Sp1-dependent activation of HDAC7 is required for platelet-derived growth factor-BB-induced smooth muscle cell differentiation from stem cells. J Biol Chem 2010;285:38463-38472.
  • Zampetaki A, Zeng L, Margariti A, et al. Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow. Circulation 2010;121:132-142.
  • Bai X, Margariti A, Hu Y, et al. Protein kinase C{delta} deficiency accelerates neointimal lesions of mouse injured artery involving delayed reendothelialization and vasohibin-1 accumulation. Arterioscler Thromb Vasc Biol 2010;30:2467-2474.
  • Margariti A, Xiao Q, Zampetaki A, et al. Splicing of HDAC7 modulates the SRF-myocardin complex during stem-cell differentiation towards smooth muscle cells. J Cell Sci 2009;122:460-470.
  • Zeng L, Zampetaki A, Margariti A, et al. Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow. Proc Natl Acad Sci U S A 2009;106:8326-8331.
  • Zeng L, Xiao Q, Margariti A, et al. HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells. J Cell Biol 2006;174:1059-1069.
  • Xiao Q, Zeng L, Zhang Z, et al. Sca-1+ progenitors derived from embryonic stem cells differentiate into endothelial cells capable of vascular repair after arterial injury. Arterioscler Thromb Vasc Biol 2006;26:2244-2251.