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and research funding helps TO ACHIEVE IT fast
our research funders
Current Projects in our Lab:
1. Elucidate the Endothelial Cell dysfunction using Induced Pluripotent Stem cells from Blood cells based on Novel Methods
a. From Healthy Donors
b. From Patient-Specific Groups
Generation of patient-specific diabetic models
Mechanism by which FSTL3 increase angiogenesis
2. Elucidation of the Mechanisms of Vascular Cell Differentiation and human blood vessel organoids
a. RNA Binding Proteins
b. Regulation of mRNA Splicing
c. Small Peptides
QKI Signalling in iPS cells Differentiation
3. Establishing Robust Direct Reprogramming approaches towards Vascular Cell lineages
a. Transcriptional Regulation
b. Epigenetic Modulation
c. Metabolic Switch
4. Regenerative Medicine; Test the functional Properties of the Reprogrammed Vascular Cells in vivo and propose potential therapeutic strategies to treat Vascular Disease
a. Angiogenesis
b. Ischemia
c. Vascular Injury/ Myocardial Infarction
d. In vivo Reprogramming
Improved neovascularization and blood flow in hind limb ischemia
Our Collaborators:
- Prof Alan Stitt Centre for Experimental Medicine Queen’s University Belfast, UK
- Prof David Grieve Centre for Experimental Medicine, Queen’s University Belfast, UK
- Prof Noemi Lois Clinical Professor Centre for Experimental Medicine, Queen’s University Belfast, UK
- Dr Sandra McAllister Clinical Lecturer Centre for Experimental Medicine, Queen’s University Belfast, UK
- Prof George Daley Boston Children’s Hospital Harvard Medical School, Boston, USA
- Dr Thorsten Schlaeger Head of pluripotent stem cells Core Facility Boston Children’s Hospital Harvard Medical School, USA
- Prof Deepak Srivastava Gladstone Institute of Cardiovascular Research in University of California, San Francisco, USA
- Dr Alisha Holloway (Bioinformatics Core) Gladstone Institute of Cardiovascular Research in Univ. of California, San Francisco, USA
- Prof Qingbo Xu BHF Centre of Excellence King’s College London, UK
- Dr Lingfang Zeng BHF Centre of Excellence King’s College London, UK
- Dr Anna Zampetaki BHF Centre of Excellence King’s College London, UK
- Prof John McCarron University of Strathclyde, Glasgow, UK
- Dr Steve Shnyder Institute of Cancer Therapeutics University of Bradford, UK
- Dr David Simpson Centre for Experimental Medicine Queen’s University Belfast, UK
- Dr Guillermo Lopez Campos Centre for Experimental Medicine Queen’s University Belfast, UK
- Dr Jose Sousa Queen’s University Belfast, UK
- Dr Fionna Wilkinson Manchester Metropolitan University, UK
- Prof Yvonne Alexander Manchester Metropolitan University, UK